Platelet-activating Factor–mediated NF-κB Dependency of a Late Anaphylactic Reaction
نویسندگان
چکیده
منابع مشابه
Platelet-activating Factor–mediated NF-κB Dependency of a Late Anaphylactic Reaction
Anaphylaxis is a life-threatening systemic allergic reaction with the potential for a recurrent or biphasic pattern. Despite an incidence of biphasic reaction between 5 and 20%, the molecular mechanism for the reaction is unknown. Using a murine model of penicillin V-induced systemic anaphylaxis, we show an autoregulatory cascade of biphasic anaphylactic reactions. Induction of anaphylaxis caus...
متن کاملThe effect of platelet activating factor on the motility and acrosome reaction of ram spermatozoa
Platelet activating factor (PAF) is a novel signaling phospholipids that in addition to platelet activation has many biological properties. The acrosome reaction, as an essential step in mammalian fertilization, can occur in response to several agents such as PAF. Therefore, the present study aimed to assess the effect of PAF on the motility and acrosome reaction of ram spermatozoa. Semen was c...
متن کاملBmi-1 Promotes Glioma Angiogenesis by Activating NF-κB Signaling
Angiogenesis in glioma is associated with the poor prognosis of the disease and closely correlates with the highly invasive phenotype of glioma cells, which represents the most challenging impediment against the currently glioma treatments. Bmi-1, an onco-protein, has been implicated in the progression of various human cancers, including gliomas, whereas its role in glioma angiogenesis remains ...
متن کاملNuclear Factor B Dependency of Platelet-activating Factor-induced Angiogenesis
This study investigated the mechanisms of platelet-activating factor (PAF)-induced angiogenesis in a mouse model of Matrigel implantation. PAF induced a doseand time-dependent angiogenic response. Inhibitors of nuclear factor (NF) B expression or action, including antisense oligonucleotides to the p65 subunit of NF B (p65 antisense) and antioxidants such as -tocopherol and N-acetyl-L-cysteine, ...
متن کاملImpaired Anaphylactic Responses with Intact Sensitivity to Endotoxin in Mice Lacking a Platelet-activating Factor Receptor
Platelet-activating factor (PAF) is a potent phospholipid mediator with diverse biological activities in addition to its well-known ability to stimulate platelet aggregation. Pharmacologic studies had suggested a role for PAF in pregnancy, neuronal cell migration, anaphylaxis, and endotoxic shock. Here we show that disruption of the PAF receptor gene in mice caused a marked reduction in systemi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2003
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.20022129